Endocrine Abstracts

Introduction: Pheochromocytoma is a rare tumor originating from chromaffin cells of the adrenal medulla secreting catecholamines. The typical symptoms of pheochromocytoma include hypertension, headache, heart palpitations, anxiety, and profuse sweating. However, some patients with pheochromocytomas remain asymptomatic. The aim of this study was to determine the clinical and paraclinical characteristics of incidentally discovered pheochromocytomas.Methods...

Introduction: The insulin tolerance test (ITT) is the gold standard for hypothalamic-pituitray adrenal axis assessment. An adequate response of serum cortisol level above or equal to 18 μg/dl confirms the integrity of the adrenal axis. Otherwise, it confirms adrenal insufficiency (AI). The aim of our study was to investigate clinical and biological factors for the prediction of an adequate response during the ITT.Methods: We conducted a cross-sectio...

Introduction: The insulin tolerance test (ITT) is commonly used for the evaluation of the corticotropic axis. There are different protocols depending on the number and timing of blood samples. The aim of our study was to investigate the predictive factors of a late response during ITT.Methods: Our study was cross-sectional and descriptive. One hundred patients with suspected adrenal insufficiency (AI) were evaluated. An intravenous rapid insulin bolus of...

Introduction: Hypothyroidism is a prevalent endocrine disease among the elderly. The thyroid hormones have a wide range of effects on the body, and hypothyroidism can significantly impact both physical and mental functions. The objectives of this study were to evaluate the quality of life in patients over 65 years old with substituted hypothyroidism and to assess their relationship with Thyroid Stimulating Hormone (TSH) level.Methods: The study was a cro...

Introduction: Antithyroid drugs are the firstline medical treatment for hyperthyroidism in addition to symptomatic treatment (rest, beta-blockers). The most widely used in Tunisia is Thiamazole. They are generally well tolerated, but side effects have been reported. The most serious ones are agranulocytosis and liver damage. Allergic skin reactions (pruritus, urticaria) are the most common. We herein report a case of a lichenoid dermatitis bullous toxidermia induced by Thiamaz...

Introduction: In patients with Graves’ disease, uncontrolled thyrotoxicosis causes liver dysfunction in 37 to 78% of cases. This is commonly revealed by abnormal elevation of liver enzymes including hepatic cytolysis and cholestasis. The aim of the present study was to determine the prevalence of liver dysfunction and its associated factors in patients with Graves’ disease.Methods: This was a monocentric retrospective study including 108 patien...

Introduction: Hashimoto’s thyroiditis is the most frequent cause of hypothyroidism with a relative increased risk of thyroid lymphoma compared to healthy subjects. Hyperfunctioning nodules are rarely malignant. We report the case of a rare association of thyroid carcinoma, a hyperfunctioning nodule and Hashimoto thyroiditis.Observation: We report the case of a 40-year-old female patient treated with L-thyroxine for hypothyroidism due to Hashimoto th...

Introduction: Thyroid cancer remains a relatively rare entity. Radiological scoring systems aim to stratify the risk of malignancy based on morphological criteria.The objective of this study was to develop a new score based on ultrasound criteria to predict thyroid nodule malignancy risk.Patients and methods: This was a retrospective study including 200 thyroid nodules (100 malignant nodules and 100 benign nodules). The report of the thyroid ultrasound a...

Introduction: Polycystic ovary syndrome is the most common cause of anovulatory infertility in women. Anti-Mullerian Hormone (AMH) was considered a reliable marker for the diagnosis of polycystic ovary syndrome (PCOS). However, AMH level is influenced by age and body mass index. The aim of this study was to analyze the performance of the (LH x AMH)/FSH ratio in the diagnosis of PCOS in women with morbid obesity.Methods: This was a cross-sectional study i...

Introduction: Statins are used in the management of hypercholesterolemia and the prevention of cardiovascular diseases. However, by reducing cholesterol biosynthesis, steroidogenesis and particularly testosterone synthesis may be affected. The aim of our study was to assess the effect of high doses of statin therapy on testosterone levels in type 2 diabetes male patients.Methods: This was a single-center, prospective study, during the period march 2021 -...